During the past 70 years, there have been dozens of studies published in respected journals - all reporting the beneficial effects of negative ions. 

1935 Journal of Industrial Hygiene
The Effect of High Concentrations of Light Negative Atmosperic Ions on the Growth and Activity of the Albino Rat
Researchers Herrington and Smith found that rats displayed a significant increase in activity (measured by an activity wheel) when subjected to a negative ion concentration of 1.2 million ions per cubic centimeter.

1965 Psychophysiology
Behavioral Effects of Ionized Air on Rats
Researchers Duffe and Koontz studied the effects of negatively ionized air on the mental functioning of rats. They reported that their water-maze performance improved by 350%,  showing a dramatic improvement in cognitive functioning.

1967 Journal of Comparitive and Physiological Psychology

Allan H. Frey at the Insitute for Research, Pennsylvania State University noted that animals were less inhibited and less likely to experience fear and anxiety when treated with negative ions. These results were similar to the anti-anxiety effects of Valium and Xanax.

1978 Ergonomics
Air Ions and Human Performance

Research was conducted at the University of Surrey, England to study the effects of artificial negative and positive ionization on the performance of psychomotor tasks with 45 healthy adults.  It was observed that
negative ionization showed a significant improvement in performance as compared to both positive ionization and ordinary air.

1981 October issue of  Human Factors

The Infuence of Negative Air Ions on Human Performance and Mood
Subjects who were exposed to a negative ion environment for fifteen minutes were more energetic and achieved faster time reactions on performance tasks than when they were in normal air conditions.

1981 December issue of Journal of Environmental Psychology
California State University asked over a hundered employees to keep daily records of their overall well-being for a three month period.  After the introduction of a negative ion generator into their office environment, employees reported an increase in overall friendliness, alertness, atmosperic freshness, and a significant reduction in the number of headache, nausea, and dizziness complaints.

1982 August issue of  Aviation, Space, and Environmental Medicine

Subjective Response to Negative Air Ion Exposure
A double-blind study was conducted at the medical research laboratory at Wright-Patterson Air Force Base in Ohio to test the psychological effects of negative ions. One group of subjects stayed in a room under normal air conditions, while another group stayed in a room filled with negative ionized air. They were both confined for six hours and monitored. The group exposed to negative ions were observed to be calmer, less irritable, less sensitive, and more responsive than the control group.

1984 Journal of Abnormal Child Psychology

Negative Air Ionization Improves Memory and Attention in Learning-Disabled and Mentally Retarded Children
The cognitive abilities of mentally handicapped children as well as normal children were tested while
exposed to a negative ion-rich environment. Short-term memory improved 8.4% for the normal children, 23.6% for the learning-disabled, and 54.8% for the mildly retarded.

1995 February issue of  Journal of Alternative and Complementary Medicine
Michale and Jiuan Su Terman, research psychologists at the New York State Psychiatric Institute at Columbia University, conducted a study to test the effects of high density ionizers on "Seasonal Affective Disorder." Subjects diagnosed with SAD were seated three feet away from a high density negative ion generator that produced 2,700,000 ions/cubic centimeter for 30 minutes a day. About 58 percent of the subjects experienced total relief from symptoms of depression. Dr. Terman believes that high density ion therapy seems to be as effective as antidepressant medications.
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